October 31, 2025 8:28am

Tomorrow, we moving-on from October to November which has a better and positive seasonality pattern

The C&GT sectors after hours trading floated negative while the pre-open indications reaffirmed probabilities

Following the impact of the overnight Trump-Xi meeting was mixed, delivering a 1-year trade truce

Pre-open Signals: 6 Positive and 2 Negative Indications

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

Coming off of a lackluster session as the sector crashed, and indexes were sluggish after closing Thursday in the red.

Thursday night’s … RMi Closing Bell: Cooling … https://www.regmedinvestors.com/articles/14175

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

 

Friday: The pre-open Dow futures are UP +0.24% or (+113 points), the S&P futures are UP +0.89% or (+61 points) and the Nasdaq futures are UP +1.45% or (+374 points)

  • Stock futures are on the rise, this last session of October, 10/31
  • European markets are lower reacting to ECB decision to hold rates steady,
  • Asia Pacific markets were mixed

 

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

  • Thursday: The Dow closed DOWN -110.07 points or -0.23%, the S&P closed DOWN -68.23 points or -0.99% while the Nasdaq closed DOWN -377.329 points or -1.58%
  • Wednesday: The Dow closed DOWN -74.37 points or -0.16%, the S&P closed DOWN -0.30 points or -0.00% while the Nasdaq closed UP +139.98 points or +0.55%
  • Tuesday: The Dow closed UP +161.78 points or +0.34%, the S&P closed UP +15.76 points or +0.23% while the Nasdaq closed UP +190.037 points or +0.80%
  • Monday: The Dow closed UP +337.47 points or +0.71%, the S&P closed UP +83.47 points or +1.23% while the Nasdaq closed UP +432.589 points or +1.86%
  • Week to date: The S&P 500 is up 1.5%, the Dow +0.9% and the Nasdaq is up +3.2%.
  • Last week: the S&P 500 was up +2%, the Dow +2% and the Nasdaq added +2%.
  • The previous week: the S&P 500 was up +1.7%, the Dow +1.6% and the Nasdaq +2.1%.
  • Last month and Q3’s numbers, the S&P 500 Q was up +7% and the month -4.2%, the Nasdaq’s Q is up +11% and the month +5% while the Dow’s Q is up +5% and the month +1%

 

Q4 – 1 neutral, 9 positive and 12 negative closes

  • Q3 – September, 1 holiday, 9 negative and 12 positive closes; August - 11 negative and 9 positive closes; July – 1 market holiday, 13 positive and 9 negative closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

  • October began with a government shutdown and much fewer econs… along with the usual ups, downs
  • Now uncertainty rules

Info:

Vertex (VRTX) closed up+$2.68 after Wednesday’s -$5.18, Tuesday’s +$2.22 and last Monday’s -$1.22 with a negative -$6.89 or -1.64% pre-open

Ionis Pharmaceuticals (IONS) closed up +$2.29 after Wednesday’s -$1.69, Tuesday’s +$0.58 and last Monday’s +$2.13 with a positive +$0.81 or +1.09% pre-open

Ultragenyx Pharmaceuticals (RARE) closed up +$0.58 with a positive +$0.95 or +2.70% pre-open

Wave Life Sciences (WVE) closed up +$0.04 after Wednesday’s +$0.67 with a negative -$0.15 or -1.76% pre-open

uniQure NV (QURE) closed down -$2.73 after Wednesday’s +$0.59, Tuesday’s +$2.08 and last Monday’s +$6.91 with a positive +$0.61 or +0.90% pre-open

CRISPR Therapeutics (CRSP) closed down -$1.46 after Wednesday’s -$1.61, Tuesday’s -$1.55 and last Monday’s -$1.89 with a positive +$0.44 or +0.72% pre-open

Intellia Therapeutics (NTLA) closed down -$0.85 after Wednesday’s -$0.84, Tuesday’s -$0.83 and Monday’s -$10.81 with a positive +$0.31 or +2.56% pre-open

Capricor Therapeutics (CAPR) closed down -$0.71 after Wednesday’s +$0.74 with a positive +$0.31 or +4.99% pre-open

 

The BOTTOM LINE: I see some green on the screen this last session of October after 7 down sessions of 9 ...

I'm stil on my computer/laptop/ my horse with a lantern as I ride yelling … “earnings are here, earnings are here”!

Q3 Earnings coming … in the front-view mirror next week … more coming

  • Vertex (VRTX) and Sarepta Therapeutics (SUPN) on 11/3, Ultragenyx Pharmaceuticals (RARE), Supernus Therapeutics (SUPN) on 11/4 followed by Regenxbio (RGNX), Moderna (MRNA) and Vericel (VCEL)

Expect earnings’ results that meet, beat or miss revenue estimates, EPS as to pricing expectations, consensus … sector earnings while LPS (loss-per-share) assumes adjustments

  • As sector earnings meet, beat or miss expectations; whipsaw actions could ensue depreciations or the stock market heads south, back pedal -- fast.

Upcoming;

  • Sarepta Therapeutics (SRPT) is soon to post loss of $0.03 per share forQ3/25. This estimate indicates a year-over-year change of -104.8%. This Q3's revenue is expected to be $346.23 million, down 25.9% from the year-ago quarter.
  • Ultragenyx Pharmaceuticals (RARE) is expected to post a Q3 loss of $0.85 per share which represents a year-over-year change of +6.6%. Revenues are expected to be $6.93 million, up 202.6% from the year-ago quarter
  • uniQure NV (QURE) is expected to post quarterly loss of $0.85 per share in its upcoming report, which represents a year-over-year change of +6.6%Revenues are expected to be $6.93 million, up 202.6% from the year-ago quarter.

 

The shutdown enters its 29th day today, with lawmakers still unable to agree on a funding bill … as Democrats block the 13th voting negotiation

Welcome to my world of defining the “grey’ in our universe!

  • “I hate to be so negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”
  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

October: understand the new “flow” …

New week:

  • 10/30 - Thursday closed negative with 13 positive, 25 negative and 2 flats
  • 10/29 - Wednesday closed negative with 9 positive, 30 negative and 1 flat
  • 10/28 -Tuesday closed negative with 16 positive, 21 negative and 3 flats
  • 10/27- Monday closed negative with 18 positive, 22 negative and 0 flats

Last week:

  • 10/24 - Friday closed positive with 25 positive, 13 negative and 2 flats
  • 10/23 – Thursday closed negative with 15 negative, 22 negative and 3 flats
  • 10/22 – Wednesday closed negative with 4 positive, 34 negative and 2 flat
  • 10/21 - Tuesday closed negative with 17 positive, 23 negative and 0 flat
  • 10/20 - Monday closed positive with 34 positive, 4 negative and 2 flats

 

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.