December 1, 2025 7:58am

December gambles with/into risk with potential rotation churn 

Pre-open Signals: 1 Positive and 5 Negative

Never leave an investor uninformed … I say what others won’t, so you can do what others can’t!

RMi Research Note: Harvard Apparatus GT (OTCQB): Broke … https://www.regmedinvestors.com/articles/13812

Friday’s RMi Closing Bell: November ends with a squeaky tick … https://www.regmedinvestors.com/articles/14210

Remember that overnight and pre-open actions’ futures and markets doesn’t necessarily translate into actual trading in today’s market session.

 

Monday: The pre-open Dow futures are DOWN -0.47% or (-226 points), the S&P futures are DOWN -0.72% or (-49 points) and the Nasdaq futures are DOWN -0.97% or (-246 points)

  • Stock futures are down
  • European stocks started new month in red,
  • Asia Pacific markets traded mixed with China factory activity weakening unexpectedly.

 

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

  • Friday: The Dow closed UP +289.30 points or +0.61%, the S&P closed UP +36.48 points or +0.54% while the Nasdaq closed UP +150.996 points or +0.65%
  • Thursday was a holiday
  • Last week: The S&P 500 increased +4%. the Dow +3% and the Nasdaq jumped 4%.
  • The previous week: The S&P 500 was down -2%, the Dow -2% and the Nasdaq was down -2.7%
  • The month ended: the S&P 500 and Dow were slightly higher, thanks to this week’s gains and the Nasdaq fell 2%,

 

Q4 – December, 1st session

  • November, 1 holiday, 8 positive and 11 negative sessions
  • October, 1 neutral, 10 positive and 12 negative closes

 

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

  • Pre-open, I take the top 10 and bottom 10 of the previous session's (Friday) closes to measure the potential of the morning’s possibles ...

Vertex (VRTX) closed up +$1.44 after Thursday’s holiday, Wednesday’s +$2.35, Tuesday’s +$5.82 and Monday’s -$2.76 with a negative -$4.21 or -0.97% pre-open

Ultragenyx Pharmaceuticals (RARE) closed up +$0.99 with a negative -$0.05 or -0.14 pre-open

Moderna (MRNA +$0.97 with a negative -$1.12 or -4.31% pre-open

BioNTech (BNTX) +$0.45 after Thursday’s holiday, Wednesday’s +$2.99, Tuesday’s +$317 and Monday’s +$0.95 with a negative -$2.10 or -2.04% pre-open

IQVIA Holdings (IQV) closed down -$1.79 after Thursday’s holiday, Wednesday’s -$0.02, Tuesday’s +$3.61 and Monday’s +$3.28 with a negative -$1.13 or -0.49% pre-open

Adverum Biotechnologies (ADVM -$0.04 with a positive +0.20 or +4.85% pre-open

 

The BOTTOM LINE: Still feeling the what … uncertainty!

Welcome to my world of defining the “grey’ in our universe!

  • As the leading voice of cell and gene therapy investors; I am NOT always a doom and gloom analyst/journalist but a man who has been “there” (BUY, SELL, VC and multiple operating roles) with the gray hair and a readership following with real numbers to prove it!
  • I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

 

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.