RMi Pre-opening: Tale of a shaky market and C> sector

February 9, 2026 7:31am

More econs this week, the Fed’s perceived command of inflation will be covered this week with the release of the January jobs report and the consumer price index.

Earnings: 4 this week, Thursday- Alnylam Pharmaceuticals (ALNY), Vertex (VRTX) and Ultragenyx Pharmaceuticals (RARE) and on Friday - Moderna (MRNA)

Pre-open Signals: 3 negative and 2 Positive Indications after a number of drops from aftermarket; If you understand probabilities, the inevitable is easier to maneuver

Remember that overnight action in futures don't necessarily translate into actual trading in today’s regular stock market session.

Never leave retail investor uninformed … I say what others won’t, so you can do what others can’t!

“I hate to be considered negative or contrarian but, this is a NO spin zone and truth is its product; I can always be WRONG but, I am mostly EARLY!”

Friday’s RMi Closing Bell: Bounding from the rout … https://www.regmedinvestors.com/articles/14302

I chose to speak-up when many analysts, brokers and commentators have shut-up!

Monday: The pre-open Dow futures are DOWN -0.15% or (-75 points), the S&P futures are DOWN -0.31% or (-21 points) and the Nasdaq futures are DOWN -0.52% or (-130 points)

• U.S. stock futures fluctuate down on Monday, 29
• European markets were on fire rising to new records,
• Asia Pacific markets rose with Japan hitting new records

Economic Data: 2 Fed gov i.e., talking heads: Atlanta’s Bostic, 2 Fed governor’s Waller and Miran speak (also with a podcast)

• This week brings two of the most important economic data releases in the same calendar week, a rare occurrence because of the brief government shutdown earlier this month. The Bureau of Labor Statistics will release the January jobs report on Wednesday and the consumer price index on Friday.

Henry’omics: We need to more than consider the market’s setting to grasp the micro re “our” universe of cell and gene therapy companies

• Friday: The Dow closed UP 1,206.95 points or +2.47%, the S&P closed UP +133.90 points or +1.97% while the Nasdaq closed UP +490.627 points or +2.18%
• Thursday: The Dow closed DOWN -592.58 points or -1.20%, the S&P closed DOWN -84.34 points or -1.23% while the Nasdaq closed DOWN -363.993 points or -1.59%
• Wednesday: The Dow closed UP +259.91 points or +0.53%, the S&P closed DOWN -35.06 points or -0.51% while the Nasdaq closed DOWN -350.606 points or -1.51%
• Tuesday: The Dow closed DOWN -166.67 points or -0.34%, the S&P closed DOWN -58.63 points or -0.84% while the Nasdaq closed DOWN -336.9222 points or -1.43%
• Last Monday: The Dow closed UP +515.19 points or +1.05%, the S&P closed UP +37.41 points or +0.54% while the Nasdaq closed UP +130.292 points or +0.56%

• Last week: The S&P 500 closed down -0.1%, the Nasdaq fell -1.84% and the Dow rose +2.5%
• The previous week: The S&P 500 closed up +0.04% and the Nasdaq -0.2%, while the Dow dropped -0.2%.
• January: The S&P 500, Dow were up more than 1% and the Nasdaq had a 0.7% gain.

Q1/26 – Q1 February – 2 positive and 3 negative closes

• January – 2 holiday, 2 neutral, 9 negative and 9 positive closes  

Q4 – December,

• 1 holiday, 8 positive and 12 negative closes
• November, 1 holiday, 8 positive and 11 negative sessions
• October, 1 neutral, 10 positive and 12 negative closes

Companies in my headlights – It’s your decision; I provide ideas and context

I post about “indication intelligence” looking toward investment conferences … to assist investors with insight into sector vulnerabilities and strengths.  A dictionary definition of “indicate” refers to something less than a certainty; an indication could be a signal of being oversold or overbought, a recommendation, or grounds for inferring or a basis for believing.

• Multiple earnings next week as sector releases Qs and FY25 …

Vertex (VRTX) closed up +$19.11 after Thursday’s -$11.71, Wednesday’s +$4.91, Tuesday’s -$6.40 and Monday’s +$2.11 with a negative -$1.98 or -0.41% pre-open

uniQure NV (QURE) closed up +$1.13 after Thursday’s -$2.13 after Wednesday’s -$1.15, Tuesday’s +$3.10 and Monday’s +$1.98 with a positive +$0.95 or +3.70% pre-open

Alnylam Pharmaceuticals (ALNY) closed down -$3.08 after Thursday’s -$20.72, Wednesday’s +$0.16, Tuesday’s +$12.69 and Monday’s +$1.05 with a negative -$0.16 or -0.05% pre-open

BioNTech (BNTX) closed up +$1.08 after Thursday’s -$3.23 after Wednesday’s +$0.52 after Tuesday’s -$0.63 after Monday’s -$4.87 with a positive +$0.73 or +0.68% pre-open

Moderna (MRNA) closed up +$0.14 after Thursday’s -$1.90 after Wednesday’s +$0.57 after Tuesday’s -$0.35 after Monday’s -$1.52 with a positive +0.07 or +0.17%% pre-open

The BOTTOM LINE: Welcome to my world of defining the “grey’ in our universe!

It won’t continue, the questions, what is “it” …

• In Friday’s session, the Dow surged 1,200 points, or about 2.5%, to score its first close above 50,000 after hitting that level for the 1^st time earlier in intraday trading.
• The S&P 500 rose about 2% and the Nasdaq finished more than 2% higher.
• After an eight-day losing streak, buyers finally stepped back into the software space on Friday,
• underpinning a much-needed relief rally as the tech sector approached key support near the November lows,” said Adam Turnquist, chief technical strategist at LPL Financial.
• “While this marked a step in the right direction, the broader tech complex remains rangebound until it can decisively break above the December highs.” <CNBC>

Since, the Q4 and FY25 earnings reporting cycle ….

• Thursday - 2/12 - Alnylam Pharmaceuticals (ALNY), Vertex (VRTX) and Ultragenyx Pharmaceuticals (RARE)
• Friday - 2/13 – Moderna (MRNA)

Welcome to my world of defining the “grey’ in our universe!

• I hate to be so negative or contrarian but, this is a NO spin zone and facts and truth are its products; I can always be WRONG but, I am mostly EARLY!
• if I wanted to be liked, I wouldn’t have been an analyst/journalist.

February continues …

• 2/6 – Friday closed positive with 35 incliners, 5 decliners and 0 flat
• 2/5 -Thursday closed negative with 2 incliners, 36 decliners and 2 flats
• 2/4 -Wednesday closed negative with 10 incliners, 29 decliners and 1 flat
• 2/3 - Tuesday closed negative with 18 incliners, 21 decliners and 1 flat    
• 2/2 - Monday closed positive with 29 incliners, 10 decliners and 1 flat

January – the last week:

• 1/30 – Friday closed negative with 6 incliners, 32 decliners and 2 flat
• 1/29 - Thursday closed positive with 22 incliners, 17 decliners and 1 flat
• 1/28 - Wednesday closed negative with 4 incliners, 35 decliners and 1 flat
• 1/27 - Tuesday closed positive with 21 incliners, 19 decliners and 0 flat
• 1/26 -Monday closed positive with 19 incliners, 18 decliners and 3 flats

As the leading voice of cell and gene therapy investors; I am NOT always a doom and gloom analyst/journalist but a man who has been “there” (BUY, SELL, VC and multiple operating roles) with the gray hair and a readership following with real numbers to prove it!

• I am more frequently right than consequentially wrong; if I wanted to be liked, I wouldn’t have been an analyst/journalist.

Opinions expressed are those of the author and are subject to change, and not intended to be a forecast of future events, a guarantee of future results, nor investment advice. All investments are subject to risks. Investors should consider investment objectives.

Whether information or intelligence is good, bad or somewhere in between; I put into context what is relevant and useful for investors.  All investments are subject to risks. Investors should consider investment objectives.  Regulation Analyst Certification (Reg AC):

The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and it’s or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed.